WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Homologous recombination       ID:03440
C=28; O=2; E=0.07; R=29.62; rawP=0.0021; adjP=0.0189
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000106399 NA RPA3 replication protein A3, 14kDa 6119 ENSG00000106399
2  ENSG00000196584 NA XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 7516 ENSG00000196584


Database:KEGG pathway       Name:TGF-beta signaling pathway       ID:04350
C=84; O=2; E=0.20; R=9.87; rawP=0.0177; adjP=0.0398
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000115170 NA ACVR1 activin A receptor, type I 90 ENSG00000115170
2  ENSG00000133740 NA E2F5 E2F transcription factor 5, p130-binding 1875 ENSG00000133740


Database:KEGG pathway       Name:Peroxisome       ID:04146
C=79; O=2; E=0.19; R=10.50; rawP=0.0157; adjP=0.0398
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000115425 NA PECR peroxisomal trans-2-enoyl-CoA reductase 55825 ENSG00000115425
2  ENSG00000163344 NA PMVK phosphomevalonate kinase 10654 ENSG00000163344


Database:KEGG pathway       Name:Endocytosis       ID:04144
C=201; O=3; E=0.48; R=6.19; rawP=0.0129; adjP=0.0398
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000139722 NA VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 79720 ENSG00000139722
2  ENSG00000147010 NA SH3KBP1 SH3-domain kinase binding protein 1 30011 ENSG00000147010
3  ENSG00000165731 NA RET ret proto-oncogene 5979 ENSG00000165731


Database:KEGG pathway       Name:RNA transport       ID:03013
C=151; O=2; E=0.36; R=5.49; rawP=0.0517; adjP=0.0842
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000132182 NA NUP210 nucleoporin 210kDa 23225 ENSG00000132182
2  ENSG00000156508 NA EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1915 ENSG00000156508


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=6; E=2.72; R=2.20; rawP=0.0561; adjP=0.0842
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000170835 NA CEL carboxyl ester lipase (bile salt-stimulated lipase) 1056 ENSG00000170835
2  ENSG00000166123 NA GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 84706 ENSG00000166123
3  ENSG00000161714 NA PLCD3 phospholipase C, delta 3 113026 ENSG00000161714
4  ENSG00000064225 NA ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 10402 ENSG00000064225
5  ENSG00000163344 NA PMVK phosphomevalonate kinase 10654 ENSG00000163344
6  ENSG00000156471 NA PTDSS1 phosphatidylserine synthase 1 9791 ENSG00000156471


Database:KEGG pathway       Name:Calcium signaling pathway       ID:04020
C=177; O=2; E=0.43; R=4.69; rawP=0.0684; adjP=0.0879
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000161714 NA PLCD3 phospholipase C, delta 3 113026 ENSG00000161714
2  ENSG00000005022 NA SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 292 ENSG00000005022


Database:KEGG pathway       Name:Cytokine-cytokine receptor interaction       ID:04060
C=265; O=2; E=0.64; R=3.13; rawP=0.1344; adjP=0.1512
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000115170 NA ACVR1 activin A receptor, type I 90 ENSG00000115170
2  ENSG00000158813 NA EDA ectodysplasin A 1896 ENSG00000158813


Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=2; E=0.79; R=2.54; rawP=0.1858; adjP=0.1858
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000165731 NA RET ret proto-oncogene 5979 ENSG00000165731
2  ENSG00000114251 NA WNT5A wingless-type MMTV integration site family, member 5A 7474 ENSG00000114251




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).